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Surface-enhanced Raman Spectroscopy-based High-throughput Toxicology Drug Screening
Monday, March 08, 2021: 4:05 PM - 4:25 PM
Speaker(s)
Description
Nationally, the Center for Disease Control and Prevention (CDC) reports that during 2016 nearly 64,000 people died from drug overdoses. Also, from July 2017 to September 2017, the CDC reports increases in opioid overdoses of 30% in 45 states and 70% in the Midwest alone. Therefore, there is an unmet need for the development of widely applicable, non-destructive, less costly, quantitative, and analytical techniques, which will be able to detect and quantify drugs in a wide range of biofluids (e.g., plasma, whole blood, urine, sweat, and saliva) at the bedside and roadside. The search for dangerous new drugs further complicates matters for forensic toxicology by imposing greater methodological challenges for analytical chemists, and postmortem and clinical toxicologists. To overcome the current bottleneck in forensic toxicology, we have fabricated an entirely new nanoplasmonic sensor for surface-enhanced Raman spectroscopy (SERS)-based drug screening. The SERS-based nanosensors are prepared by assembling poly (ethylene glycol) thiolate-functionalized gold triangular nanoprisms (Au TNPs) in which strong electromagnetic field coupling between adjacent TNPs provides a strong SERS enhancement that allows to quantify fentanyl and its analogous, cocaine, and heroin at femtogram/microliter concentrations. We fabricated the sensor via a bottom up chemical lithographic technique. To further demonstrate the utility of our developed nanosensors in actual forensic toxicology, we have analyzed 20 drug overdose patient samples from the emergency department from a single instrument run, justifying the term high-throughput assay. Our work represents a transformative step towards simplifying forensic toxicology, particularly for rapid analysis. Furthermore, our technology does not need large sample amounts, a specific laboratory environment, highly trained personnel for analysis, and expensive sample processing.
Additional Info
Keywords: Please select up to 4 keywords ONLY:
Surface Enhanced Raman Spectroscopy,Clinical Analysis,Nanoscience
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